Exploring the Role of Short Tandem Repeats (STR) in Forensic Biotechnology: Challenges and Innovations

Betelhem Abebe; Temesgen Mitiku; Nega Birhane

doi:doi:10.11648/j.ijbbmb.20240902.12

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Exploring the Role of Short Tandem Repeats (STR) in Forensic Biotechnology: Challenges and Innovations

Betelhem Abebe^*

, Temesgen Mitiku

, Nega Birhane

Published in International Journal of Biochemistry, Biophysics & Molecular Biology (Volume 9, Issue 2)

Received: 26 October 2024 Accepted: 5 December 2024 Published: 25 December 2024

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Abstract

Short tandem repeat (STR) typing remains a crucial tool in forensic DNA profiling worldwide. This technology not only helps in convicting criminals and proving wrongful convictions but also establishes essential links to actual perpetrators of crimes and can act as a deterrent to potential offenders. DNA profiling has also allowed forensic scientists to re-examine closed cases due to insufficient evidence. To conduct this review, an extensive electronic literature search was performed using databases such as PubMed, Science Direct, Google Scholar, and Google Search. All relevant works, including reviews, retrospective studies, observational studies, and original articles, were thoroughly reviewed. This paper explores the challenges and perspectives associated with using STRs in forensic investigations. STRs have high polymorphism, Mendelian inheritance, and the ability to analyze multiple loci in one reaction, making them essential tools in forensic science. Additionally, their suitability for analyzing degraded or traces DNA samples enhances their usefulness in criminal investigations and paternity testing. This abstract summarizes the current landscape of STR applications in forensic biotechnology, highlighting the challenges researchers face and the promising features that drive innovation in this field.

Published in	International Journal of Biochemistry, Biophysics & Molecular Biology (Volume 9, Issue 2)
DOI	10.11648/j.ijbbmb.20240902.12
Page(s)	42-49
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

DNA Profiling, Short Tandem Repeat, Crime Scene, Forensic, DNA Marker, Incest

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APA Style

Abebe, B., Mitiku, T., Birhane, N. (2024). Exploring the Role of Short Tandem Repeats (STR) in Forensic Biotechnology: Challenges and Innovations. International Journal of Biochemistry, Biophysics & Molecular Biology, 9(2), 42-49. https://doi.org/10.11648/j.ijbbmb.20240902.12

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ACS Style

Abebe, B.; Mitiku, T.; Birhane, N. Exploring the Role of Short Tandem Repeats (STR) in Forensic Biotechnology: Challenges and Innovations. Int. J. Biochem. Biophys. Mol. Biol. 2024, 9(2), 42-49. doi: 10.11648/j.ijbbmb.20240902.12

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AMA Style

Abebe B, Mitiku T, Birhane N. Exploring the Role of Short Tandem Repeats (STR) in Forensic Biotechnology: Challenges and Innovations. Int J Biochem Biophys Mol Biol. 2024;9(2):42-49. doi: 10.11648/j.ijbbmb.20240902.12

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@article{10.11648/j.ijbbmb.20240902.12,
  author = {Betelhem Abebe and Temesgen Mitiku and Nega Birhane},
  title = {Exploring the Role of Short Tandem Repeats (STR) in Forensic Biotechnology: Challenges and Innovations
},
  journal = {International Journal of Biochemistry, Biophysics & Molecular Biology},
  volume = {9},
  number = {2},
  pages = {42-49},
  doi = {10.11648/j.ijbbmb.20240902.12},
  url = {https://doi.org/10.11648/j.ijbbmb.20240902.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbbmb.20240902.12},
  abstract = {Short tandem repeat (STR) typing remains a crucial tool in forensic DNA profiling worldwide. This technology not only helps in convicting criminals and proving wrongful convictions but also establishes essential links to actual perpetrators of crimes and can act as a deterrent to potential offenders. DNA profiling has also allowed forensic scientists to re-examine closed cases due to insufficient evidence. To conduct this review, an extensive electronic literature search was performed using databases such as PubMed, Science Direct, Google Scholar, and Google Search. All relevant works, including reviews, retrospective studies, observational studies, and original articles, were thoroughly reviewed. This paper explores the challenges and perspectives associated with using STRs in forensic investigations. STRs have high polymorphism, Mendelian inheritance, and the ability to analyze multiple loci in one reaction, making them essential tools in forensic science. Additionally, their suitability for analyzing degraded or traces DNA samples enhances their usefulness in criminal investigations and paternity testing. This abstract summarizes the current landscape of STR applications in forensic biotechnology, highlighting the challenges researchers face and the promising features that drive innovation in this field.
},
 year = {2024}
}

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TY  - JOUR
T1  - Exploring the Role of Short Tandem Repeats (STR) in Forensic Biotechnology: Challenges and Innovations

AU  - Betelhem Abebe
AU  - Temesgen Mitiku
AU  - Nega Birhane
Y1  - 2024/12/25
PY  - 2024
N1  - https://doi.org/10.11648/j.ijbbmb.20240902.12
DO  - 10.11648/j.ijbbmb.20240902.12
T2  - International Journal of Biochemistry, Biophysics & Molecular Biology
JF  - International Journal of Biochemistry, Biophysics & Molecular Biology
JO  - International Journal of Biochemistry, Biophysics & Molecular Biology
SP  - 42
EP  - 49
PB  - Science Publishing Group
SN  - 2575-5862
UR  - https://doi.org/10.11648/j.ijbbmb.20240902.12
AB  - Short tandem repeat (STR) typing remains a crucial tool in forensic DNA profiling worldwide. This technology not only helps in convicting criminals and proving wrongful convictions but also establishes essential links to actual perpetrators of crimes and can act as a deterrent to potential offenders. DNA profiling has also allowed forensic scientists to re-examine closed cases due to insufficient evidence. To conduct this review, an extensive electronic literature search was performed using databases such as PubMed, Science Direct, Google Scholar, and Google Search. All relevant works, including reviews, retrospective studies, observational studies, and original articles, were thoroughly reviewed. This paper explores the challenges and perspectives associated with using STRs in forensic investigations. STRs have high polymorphism, Mendelian inheritance, and the ability to analyze multiple loci in one reaction, making them essential tools in forensic science. Additionally, their suitability for analyzing degraded or traces DNA samples enhances their usefulness in criminal investigations and paternity testing. This abstract summarizes the current landscape of STR applications in forensic biotechnology, highlighting the challenges researchers face and the promising features that drive innovation in this field.

VL  - 9
IS  - 2
ER  -

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Author Information

Betelhem Abebe

Department of Medical Biotechnology, Institute of Biotechnology, Dambi Dollo University, Dambi Dollo, Ethiopia

Contact Email

http://orcid.org/0009-0007-3314-3883
Temesgen Mitiku

Department of Medical Biotechnology, Institute of Biotechnology, Dambi Dollo University, Dambi Dollo, Ethiopia

http://orcid.org/0009-0005-7807-3685
Nega Birhane

Department of Medical Biotechnology, Institute of Biotechnology, University of Gondar, Gondar, Ethiopia

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APA Style

Abebe, B., Mitiku, T., Birhane, N. (2024). Exploring the Role of Short Tandem Repeats (STR) in Forensic Biotechnology: Challenges and Innovations. International Journal of Biochemistry, Biophysics & Molecular Biology, 9(2), 42-49. https://doi.org/10.11648/j.ijbbmb.20240902.12

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ACS Style

Abebe, B.; Mitiku, T.; Birhane, N. Exploring the Role of Short Tandem Repeats (STR) in Forensic Biotechnology: Challenges and Innovations. Int. J. Biochem. Biophys. Mol. Biol. 2024, 9(2), 42-49. doi: 10.11648/j.ijbbmb.20240902.12

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AMA Style

Abebe B, Mitiku T, Birhane N. Exploring the Role of Short Tandem Repeats (STR) in Forensic Biotechnology: Challenges and Innovations. Int J Biochem Biophys Mol Biol. 2024;9(2):42-49. doi: 10.11648/j.ijbbmb.20240902.12

Copy | Download

@article{10.11648/j.ijbbmb.20240902.12,
  author = {Betelhem Abebe and Temesgen Mitiku and Nega Birhane},
  title = {Exploring the Role of Short Tandem Repeats (STR) in Forensic Biotechnology: Challenges and Innovations
},
  journal = {International Journal of Biochemistry, Biophysics & Molecular Biology},
  volume = {9},
  number = {2},
  pages = {42-49},
  doi = {10.11648/j.ijbbmb.20240902.12},
  url = {https://doi.org/10.11648/j.ijbbmb.20240902.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbbmb.20240902.12},
  abstract = {Short tandem repeat (STR) typing remains a crucial tool in forensic DNA profiling worldwide. This technology not only helps in convicting criminals and proving wrongful convictions but also establishes essential links to actual perpetrators of crimes and can act as a deterrent to potential offenders. DNA profiling has also allowed forensic scientists to re-examine closed cases due to insufficient evidence. To conduct this review, an extensive electronic literature search was performed using databases such as PubMed, Science Direct, Google Scholar, and Google Search. All relevant works, including reviews, retrospective studies, observational studies, and original articles, were thoroughly reviewed. This paper explores the challenges and perspectives associated with using STRs in forensic investigations. STRs have high polymorphism, Mendelian inheritance, and the ability to analyze multiple loci in one reaction, making them essential tools in forensic science. Additionally, their suitability for analyzing degraded or traces DNA samples enhances their usefulness in criminal investigations and paternity testing. This abstract summarizes the current landscape of STR applications in forensic biotechnology, highlighting the challenges researchers face and the promising features that drive innovation in this field.
},
 year = {2024}
}

Copy | Download

TY  - JOUR
T1  - Exploring the Role of Short Tandem Repeats (STR) in Forensic Biotechnology: Challenges and Innovations

AU  - Betelhem Abebe
AU  - Temesgen Mitiku
AU  - Nega Birhane
Y1  - 2024/12/25
PY  - 2024
N1  - https://doi.org/10.11648/j.ijbbmb.20240902.12
DO  - 10.11648/j.ijbbmb.20240902.12
T2  - International Journal of Biochemistry, Biophysics & Molecular Biology
JF  - International Journal of Biochemistry, Biophysics & Molecular Biology
JO  - International Journal of Biochemistry, Biophysics & Molecular Biology
SP  - 42
EP  - 49
PB  - Science Publishing Group
SN  - 2575-5862
UR  - https://doi.org/10.11648/j.ijbbmb.20240902.12
AB  - Short tandem repeat (STR) typing remains a crucial tool in forensic DNA profiling worldwide. This technology not only helps in convicting criminals and proving wrongful convictions but also establishes essential links to actual perpetrators of crimes and can act as a deterrent to potential offenders. DNA profiling has also allowed forensic scientists to re-examine closed cases due to insufficient evidence. To conduct this review, an extensive electronic literature search was performed using databases such as PubMed, Science Direct, Google Scholar, and Google Search. All relevant works, including reviews, retrospective studies, observational studies, and original articles, were thoroughly reviewed. This paper explores the challenges and perspectives associated with using STRs in forensic investigations. STRs have high polymorphism, Mendelian inheritance, and the ability to analyze multiple loci in one reaction, making them essential tools in forensic science. Additionally, their suitability for analyzing degraded or traces DNA samples enhances their usefulness in criminal investigations and paternity testing. This abstract summarizes the current landscape of STR applications in forensic biotechnology, highlighting the challenges researchers face and the promising features that drive innovation in this field.

VL  - 9
IS  - 2
ER  -

Copy | Download